IgE
Immunoglobulin E (IgE) is the protein in antibodies associated with allergic responses and is produced when allergens enter the body, consequently resulting in an allergic reaction [1].
IgE has a molecular weight of 200 kDA, 5 domains and a ε chain.
IgE is found in very low concentrations in serum and plays an important role in imflammation due to its high affinity to binding to FcRs (Fc receptors) on mast cells which casues mast cell degranulation.
References
- ↑ Silverthorn, Dee Unglaub., Johnson, Bruce R., Ober, William C., Garrison, Claire W., Silverthorn, Andrew C.(2009)Human Physiology: An integrated approach, 5th edition, New York: Pearson International. p795