SSRI

SSRI is an acronym for Selective Serotonin Reuptake Inhibitor. SSRIs are antidepressants ^[1] that work by inhibiting serotonin (a.k.a. 5-hydroxytryptamine or 5-HT) re-uptake. Unlike tricyclic antidepressants (TCAs) and serotonin/norepinephrine reuptake inhibitors (SNRIs), SSRIs have greater selectivity for the serotonin transporter than to norepinephrine transporter (Whalen, Finkel & Panavelil, 2015, p. 136)^[2]. Therefore, SSRIs are more specific, inhibiting only serotonin reuptake (Whalen, Finkel & Panavelil, 2015, p. 136)^[2]. This in turn will increase the serotonin level across the synaptic cleft.

Some examples of SSRIs include fluoxetine, paroxetine and sertraline ^[1].

References

↑ ^1.0 ^1.1 Rang, H.P., Dale, M.M., Ritter, J.M., Flower, R.J. and Henderson, G., 2011. Rang and Dale's Pharmacology 7th ed. London:Elsevier Inc.
↑ ^2.0 ^2.1 WHALEN, K., FINKEL, R. and PANAVELIL, T.A., (2015) Lippincott Illustrated Reviews: Pharmacology. 6th Ed. Philadelphia: Wolters Kluwer.

[[1]-1] 1.0 ^1.1 Rang, H.P., Dale, M.M., Ritter, J.M., Flower, R.J. and Henderson, G., 2011. Rang and Dale's Pharmacology 7th ed. London:Elsevier Inc.

[[2]-2] 2.0 ^2.1 WHALEN, K., FINKEL, R. and PANAVELIL, T.A., (2015) Lippincott Illustrated Reviews: Pharmacology. 6th Ed. Philadelphia: Wolters Kluwer.

[1]

[2]

SSRI

References

Navigation menu

Search