Initiation of DNA Replication

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DNA replication is initiated from fixed origins which includes repeated sequences. For initiation of replication, two things are essential:

  • A nucleotide sequence that binds to initiation proteins.
  • Generation of a primer which can be extended with the help of DNA polymerase by adding nucleotides. [1]
  1. ↑ Mathews et al., (2000) Biochemistry 3rd Edition, Pg 909
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