Initiation of DNA Replication

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 DNA replication is initiated from fixed origins which includes repeated sequences.  For initiation of replication, two things are essential:

  • A Nucleotide sequence that binds to initiation proteins.
  • Generation of a primer which can be extended with the help of DNA polymerase by adding nucleotides.

<ref>Mathews et al. 2000. Biochemistry. 3rd Edition. Benjamin Cummings. Pg 909.</ref>

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