ADP-ribosylation

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ADP-ribosylation is where ADP-ribose polymers are covalently bonded to a protein[1]. There are a number of ways in which we can detect proteins which have been ADP-ribosylated, for example, there are a number of proteomic approaches. Some of these include; using antibodies specific to ADP-ribose and boronate affinity chromatography, or by using protein microarrays, which is a more recent method[2].

References

  1. Nature.com. PolyADP-ribosylation. http://www.nature.com/subjects/polyadp-ribosylation
  2. vivelo C A, Leung A K L. Proteomics Approaches to Identify Mono(ADP-ribosyl)ated and Poly(ADP-ribosyl)ated protein. NCBI. 2015;15(0):203-217
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