ATPase

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ATPases are a group of enzymes in which ATP is hydrolysed to ADP + Pi, therefore they are involved in the Primary Active Transport of solutes. ATPase is used in a large veriaty of cellular activities from the binding of DnaA to gene to amino acid degradation [1]. ATPase's are often used to pump ions across the cell membrane against their concentration gradient, know ions are that show this are H+, Na+, Cu2+, some also transport phospholipids with amino acid head groups[2].

The most commonly know ATPase is the sodium/potassium pump which actively transports three sodium ions out of the cell and two potassium ions into the cell for each ATP that it hydrolyzes setting up an electrochemical gradient [3]. Without this particular ATPase as with many others the body simply could not function correctly, thus ATPase's are extremely important enzymes within the cell.

References

  1. ( Biochemistry, 6th Edition, Jeremy M. Berg, John L. Tymoczko, Lubert Stryer, W. H. Freeman and Company, New York, 2008)
  2. ( Biochemistry, 6th Edition, Jeremy M. Berg, John L. Tymoczko, Lubert Stryer, W. H. Freeman and Company, New York, 2008)
  3. (http://www.weizmann.ac.il/Biological_Chemistry/scientist/Karlish/steve_karlish.pdf , Professor Steven J D Karlish, Weizman institute of science, 2008)
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