High Altitude Pulmonary Edema (HAPE)

From The School of Biomedical Sciences Wiki
Jump to: navigation, search

High Altitude Pulmonary Edema (HAPE) is a life-threatening illness which occurs at high altitude. It develops from acute mountain sickness, more commonly known as altitude sickness[1]. At higher altitudes the air pressure decreases and so the oxygen atoms are more spread out in air, this means that with each breath less oxygen is breathed in.

High altitude pulmonary edema occurs at above 3000m due to people ascending in altitude too quickly without proper acclimatisation. It is caused by the alveoli in the lungs becoming hypoxic which leads to the vasoconstriction of the pulmonary blood vessels. This vasoconstriction causes an increase in capillary pressure and in turn an increase in hydrostatic pressure[2]. The increase in capillary and hydrostatic pressure causes damage to capillary walls which leads to the edema. This negatively effects oxygen delivery as there is now an increased diffusion distance[3].

Symptoms[4] :
The symptoms of HAPE include two or more of the following:

If an individual is experiencing these symptoms, they should either seek hyperbaric treatment, supplement oxygen or descend to a lower altitude as quickly as possible[5]to prevent the development of HAPE to the more serious High Altitude Cerebral Edema (HACE)[6].

References:

  1. Swapnil J. Paralikar, High Altitude Pulmonary Edema: Clinical features, pathophysiology, prevention and treatment. Indian Journal of occupational and environmental medicine, 2012; 16(2): 59-62
  2. Swapnil J. Paralikar, High Altitude Pulmonary Edema: Clinical features, pathophysiology, prevention and treatment. Indian Journal of occupational and environmental medicine, 2012; 16(2): 59-62
  3. Peter Bärtsch, Heimo Mairbäurl, Marco Maggiorini, Erik R. Swenson, Physiological aspects of high-altitude pulmonary edema. Journal of applied physiology, March 2005; 98(3):1101-1110
  4. NHS, Altitude Sickness, Aphttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617508/ril 2017, cited 21/10/2017
  5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617508/
  6. Swapnil J. Paralikar, High Altitude Pulmonary Edema: Clinical features, pathophysiology, prevention and treatment. Indian Journal of occupational and environmental medicine, 2012; 16(2): 59-62
Personal tools
Namespaces
Variants
Actions
Navigation
Toolbox