HindIII

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HindIII is a restriction endonuclease which is often used in recombinant technology. When the specific palindromic base sequence of AAGCTT is present alongside cofactor Mg2+ then HindIII will cleave the sequence[1]. 

References:

  1. D. Tang, S. Ando, Y. Takasaki, J. Tadano. "Mutational analyses of restriction endonuclease—HindIII mutant E86K with higher activity and altered specificity". Protein Engineering, Design and Selection, 2000. Volume 13, Issue 4, Pages 283–289.