Hippocampal synaptic plasticity

Hippocampal synaptic plasticity is the relationship between the neuronal memory and cellular mechanisms and synaptic plasticity of the hippocampus. There are studies present which indicate that suggest hippocampal functions are important for higher cognitive function (e.g. impairment leads to cognitive problems in Huntington's). However, approaches are being brought in to help repair and improve damage to hippocampal synaptic plasticity - for example, Leptin-deficient mice have shown to have impaired hippocampal synaptic plasticity. Increasing Leptin levels made long-term potentiation possible and improved the memory of the deficient mice.