Histone Acetyltransferases

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An enzyme responsible for the acetylation of lysine residues (by adding an acetyl group) on the N-terminal tails on mRNA during post-translational modification. This is large multi-subunit complex that associates with a number of proteins, including the families GNAT, MYST and p300/CBP[1]. This in turn is a form of transcriptional regulation as it causes the disruption of chromatin structure.

References

  1. Sterner, D. E. and Berger, S. L. (2000) ‘Acetylation of Histones and Transcription-Related Factors’, Microbiology and Molecular Biology Reviews, 64(2), pp. 435–459. doi: 10.1128/mmbr.64.2.435-459.2000
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