Holoenzyme

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Holoenzyme is a catalytically active enzyme that consists of apoenzyme and cofactor. Cofactors can make reactions that cannot be done by standard twenty amino acids. Cofactors are divided in two groups:

Use of the same coenzyme usually means that enzymes catalyse similar mechanisms [1].

Sigma 70 and RNA Polymerase II[2] is an example of a holoenzyme used in transcription of prokaryotes.

Reference

  1. Berg J., Tymoczko J and Stryer L. (2007) Biochemistry, 6th edition, New York: WH Freeman, p207
  2. Bourbon HM, Aguilera A, Ansari AZ et al. (2004) A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Molecular Cell 14: 553–557.
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