Mdm2

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MDM2 is an E3 ubiquitin protein ligase molecule and “marks” or tags molecules involved in tumour suppressing, such as p53[1]. MDM2 controls addition of ubiquitin (a small protein) to the structure of the p53 molecule for recognition by a proteasome for degradation. P53 acts a decision maker controlling the spread of a damaged genome due to transcriptional or translational errors by performing a cell arrest, halting any development of the cell to reduce spread of potentially cancerous cells or alternatively performing apoptosis. This process helps reduce the number of rogue cells mass producing cancer cells early to ensure survival of the organism, however MDM2 inhibits the action and it is well documented that in some cancer patients the level of p53 is very low due to inhibitory action of MDM2 degrading p53[2].

References

  1. http://www.ncbi.nlm.nih.gov/gene/4193
  2. http://omim.org/entry/191170?search=MDM2%20E3%20ubiquitination%20ligase%20protein&highlight=ligase%20proteinaceous%20mdm2%20protein%20e3%20ubiquitination

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