Poly-A tail

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The Poly-A tail is a polyadenylate sequence which is added to the 3' terminus of a eukaryotic mRNA during RNA processing. A Poly-A tail can consist up to 200 nucleotides of adenosine monophosphate, which greatly increases the stability of the mRNA. Before the addition of the Poly-A tail, the 3' terminus of a eukaryotic mRNA has been modified by exonuclease digestion.This allows the mRNA sequence to act as a substrate for the extension of Poly-A tail[1].

References

  1. Hartl D., Ruvolo M. (2012) Genetics: Analysis of Genes and Genomes, 8th edition, Burlington, MA : Jones&Bartlett Learning (Page 358)
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