Single stranded binding protein

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Single stranded binding proteins (SSBs) are also known as helix-destabilising proteins[1]. They bind to exposed single stranded DNA during DNA replication which prevents the 2 strands from re-annealing after they have been unwound by DNA helicase[2]. They also prevent interactions within the single strand of DNA such as the formation of hairpin loops[3].

References

  1. Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. Molecular Biology of the Cell. 5th Ed, New York: Garland Science. 2008.
  2. Abedon ST, Biologyaspoetry. Single-stranded binding protein. 2016.fckLRhttp://www.biologyaspoetry.com/terms/single_strand_binding_protein.html
  3. Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. Molecular Biology of the Cell. 5th Ed, New York: Garland Science. 2008.
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