Steroids make up one of the three classes of hormones based on chemical structure. They are lipophilic and act on intracellular receptors in order to regulate gene transcription and trigger a cell response. Unlike peptide hormones, steroids are produced on demand from cholesterol and released immediately following synthesis. As a result, steroid producing cells will often contain large quantities of esterified cholesterol.
Actions on Receptors
Steroids will bind to a hormone binding site which prevents an inhibitory binding complex from attactching to a specific DNA binding domain. As a result, the DNA binding site is exposed which triggers the transciption activating domain and thus alters gene transcription.
- ↑ Alberts B, Johnson A, Lewis J, Morgan D, Raff M, Roberts K, Walter P.&amp;amp;nbsp;Molecular Biology of The Cell, 6th ed. New York: Garland Science; 2015.p875-876