Thrombin is an enzyme involved in the common pathway of coagulation. It is responsible for the catalysis of the break-down of fibrinogen into insoluble polymers of fibrin, which can then coagulate to form a clot by intercalating with the platelet plug initially formed at the time of injury. This traps red blood cells in a mesh which helps to seal the injury .
- ↑ D. Silverthorn (2013) Human Physiology, An Integrated Approach, 6th Edition, USA, Pearson. Chapter 16, Page 561-564