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Erk, is a MAP kinase which is activated by Mek (MAPKK) by phosphorylation. Erk uses ATP to | Erk, is a [[MAP kinase|MAP kinase]] which is activated by [[Mek|Mek]] ([[MAPKK|MAPKK]]) by [[Phosphorylation|phosphorylation]] and is involved in the Ras signalling pathway. Erk uses [[ATP|ATP]] to phosphorylate different [[Proteins|proteins]] involved in [[Gene|gene]] expression which activates [[Transcription|transcription]]. This is part of a downstream signal - a phosphorylation cascade - beginning with a signal [[Molecule|molecule]] activating a receptor protein in the membrane <ref>Alberts et al, 2008, Molecular Biology of the cell, 5th edition, New York, Garland Science</ref>. Other than Erk and Mek there is a third MAP kinase called [[Raf|Raf]] that activates Mek. Once each MAP kinase is used it is deactivated by [[Phosphatase|phosphatase]] (removes phosphate).<br> | ||
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Latest revision as of 13:12, 30 November 2015
Erk, is a MAP kinase which is activated by Mek (MAPKK) by phosphorylation and is involved in the Ras signalling pathway. Erk uses ATP to phosphorylate different proteins involved in gene expression which activates transcription. This is part of a downstream signal - a phosphorylation cascade - beginning with a signal molecule activating a receptor protein in the membrane [1]. Other than Erk and Mek there is a third MAP kinase called Raf that activates Mek. Once each MAP kinase is used it is deactivated by phosphatase (removes phosphate).
References
- ↑ Alberts et al, 2008, Molecular Biology of the cell, 5th edition, New York, Garland Science