Troponin T: Difference between revisions
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[[Troponin|Troponin]] is composed of an activating factor, [[ | [[Troponin|Troponin]] is composed of an activating factor, [[Troponin C|troponin C]], and an inhibitory factor, [[Troponin I|troponin I]]. There is also a third factor, which binds to [[Tropomyosin|tropomyosin]] called troponin T. Troponin T is a single [[Peptide|peptide]] of 259 (mostly charged) residues. This highly charged molecule is insoluble, unless in high ionic strength conditions. Troponin T binds to actin and troponin I forming a complex that moves the tropomyosin molecule.<ref>Alberts et. al.,2015, Molecular Biology of the Cell Sixth Edition, New York, Garland Science, Page 921</ref> | ||
Troponin T is part of the troponin-linked [[Calcium|calcium]] regulation system which ultimately controls muscle contraction. In order for Ca<sup>2+</sup> sensitive contraction to occur, this requires a Ca<sup>2+</sup> receptive protein; troponin. Ca<sup>2+</sup> action on troponin activates contraction within the muscle. Troponin T regulates the function of the troponin complex as it retains the Ca<sup>2+</sup> regulating ability. Troponin T makes the neutralising action of Troponin C become sensitive to concentrations of Ca<sup>2+</sup> <ref>Setsuro Ebashi Iwao Ohtsuki. (2007): 4-5, Troponin: Regulatory Mechanisms of Striated Muscle Contraction, 1st edition, Tokyo; New York: Springer</ref>. | |||
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Latest revision as of 17:29, 30 November 2015
Troponin is composed of an activating factor, troponin C, and an inhibitory factor, troponin I. There is also a third factor, which binds to tropomyosin called troponin T. Troponin T is a single peptide of 259 (mostly charged) residues. This highly charged molecule is insoluble, unless in high ionic strength conditions. Troponin T binds to actin and troponin I forming a complex that moves the tropomyosin molecule.[1]
Troponin T is part of the troponin-linked calcium regulation system which ultimately controls muscle contraction. In order for Ca2+ sensitive contraction to occur, this requires a Ca2+ receptive protein; troponin. Ca2+ action on troponin activates contraction within the muscle. Troponin T regulates the function of the troponin complex as it retains the Ca2+ regulating ability. Troponin T makes the neutralising action of Troponin C become sensitive to concentrations of Ca2+ [2].