Troponin T

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Troponin is composed of an activating factor, troponin C, and an inhibitory factor, troponin I. There is also a third factor, which binds to tropomyosin called troponin T. Troponin T is a single peptide of 259 (mostly charged) residues. This highly charged molecule is insoluble, unless in high ionic strength conditions. Troponin T binds to actin and troponin I forming a complex that moves the tropomyosin molecule.[1]

Troponin T is part of the troponin-linked calcium regulation system which ultimately controls muscle contraction. In order for Ca2+ sensitive contraction to occur, this requires a Ca2+ receptive protein; troponin. Ca2+ action on troponin activates contraction within the muscle. Troponin T regulates the function of the troponin complex as it retains the Ca2+ regulating ability. Troponin T makes the neutralising action of Troponin C become sensitive to concentrations of Ca2+ [2].

References

  1. Alberts et. al.,2015, Molecular Biology of the Cell Sixth Edition, New York, Garland Science, Page 921
  2. Setsuro Ebashi Iwao Ohtsuki. (2007): 4-5, Troponin: Regulatory Mechanisms of Striated Muscle Contraction, 1st edition, Tokyo; New York: Springer
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