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DNA Template | DNA Template Strand (also known as the anti-sense strand), is one of the strands of DNA that is present after being unwound by the enzyme [[DNA helicase|DNA helicase]] during [[DNA transcription|transcription]] of a gene. Ribonucleotide Triphosphates (rNTPs) then align along the sense anti-sense strand by [[Watson-crick base pairing|Watson-Crick base pairing]]. In [[Eukaryotes|eukaryotes]] the ribonucleotides are then joined together by [[RNA polymerase II|RNA polymerase II]] (in prokaryotes, this is just [[RNA polymerase|RNA polymerase]]) to form a [[Pre-mRNA|pre-mRNA]] molecule that is complementary to the anti-sense strand. Transcription ends when the RNA polymerases reaches a 'stop' codon. In eukaryotes only, [[Rna splicing|splicing]] will then take place in order to remove any non-coding regions of DNA ([[Introns|introns]]) to give the final [[MRNA|mRNA strand]]. The mRNA then leaves the nucleus through a [[Nuclear pore|nuclear pore]] and is [[Translation|translated]] by [[Ribosome|ribosomes]] to form a sequence of [[Amino acids|amino acids]] and thus a protein<ref>Lodish H., Kaiser CA., Bretscher A., Amon A., Berk A., Krieger M., Ploegh H and Scott MP (2012) Molecular Cell Biology, 7th edition, New York: WH Freeman page:124</ref>. | ||
=== References === | === References === | ||
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Latest revision as of 07:42, 20 October 2018
DNA Template Strand (also known as the anti-sense strand), is one of the strands of DNA that is present after being unwound by the enzyme DNA helicase during transcription of a gene. Ribonucleotide Triphosphates (rNTPs) then align along the sense anti-sense strand by Watson-Crick base pairing. In eukaryotes the ribonucleotides are then joined together by RNA polymerase II (in prokaryotes, this is just RNA polymerase) to form a pre-mRNA molecule that is complementary to the anti-sense strand. Transcription ends when the RNA polymerases reaches a 'stop' codon. In eukaryotes only, splicing will then take place in order to remove any non-coding regions of DNA (introns) to give the final mRNA strand. The mRNA then leaves the nucleus through a nuclear pore and is translated by ribosomes to form a sequence of amino acids and thus a protein[1].
References
- ↑ Lodish H., Kaiser CA., Bretscher A., Amon A., Berk A., Krieger M., Ploegh H and Scott MP (2012) Molecular Cell Biology, 7th edition, New York: WH Freeman page:124