Introns

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[1]Introns are non-coding sequences of DNA found between coding sections known as exons in eukaryotic genes and in rare cases in some prokaryotic cells [2].

Introns are removed by splicing by the spliceosome and other associated proteins that are recruited in the process of forming mature mRNA from pre-mRNA [3].

Introns nearly always have a consensus sequence that begins with GU and ends with AG which is preceeeded by a pyrimidine rich tract that acts as a  signal for splicing. [4]

There are 3 Kind of Introns: Group I, II and III Group II are ribozymes with self catalytic activities which utilize self splicing.

References

  1. Rev. Biochem. 1995. 64:435
  2. Khan AU, Ajamaluddin M, Ahmad M.(2001 Oct) A unique group of self-splicing introns in bacteriophage T4. Indian J Biochem Biophys. 38(5):289-93.
  3. Hogg R, McGrail JC, O'Keefe RT.(Aug 2010) The function of the NineTeen Complex (NTC) in regulating spliceosome conformations and fidelity during pre-mRNA splicing. Biochem Soc Trans. 38(4):1110-5.
  4. Berg, J., Tymoczko, J. and Stryer, L. 2012. Biochemistry. Basingstoke: W. H. Freeman. P136
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