DNA binding domain: Difference between revisions

Latest revision as of 10:49, 25 October 2018

A DNA binding domain (DBD) is part of a protein with a high affinity for DNA. For example, transcription factors. DBDs have a minimum of one motif which can bind to non-sequence specific or sequence specific DNA. Structural motifs can interact with single stranded and double stranded DNA. The functions of DBDs include allowing structural changes to take place to a protein and to allow regulation of transcription^[1].

Some common examples of DBDs include:

↑ L. Swint-Kruse and K. S. Matthews. Curr Opin Microbiol. Allostery in the Lac1/ GalR Family: Variations on a Theme. 2009 Apr; 12(2): 129–137

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-A DNA binding domain is part of a protein with a high affinity for DNA, for example transcription factors.
+A [[DNA|DNA]] binding domain (DBD)&nbsp;is part of a [[Protein|protein]] with a high affinity for DNA. For example,&nbsp;[[Transcription factor|transcription factors]]. DBDs have a minimum of one [[Motif|motif]] which can bind to non-sequence specific or sequence specific [[DNA|DNA]]. [[Structural motifs|Structural motifs]] can&nbsp;interact with&nbsp;[[Single stranded binding protein|single stranded and]] [[Double helix|double stranded DNA]]. The functions of DBDs include allowing structural changes to take place to a protein and to allow regulation of [[Transcription|transcription]]<ref>L. Swint-Kruse and K. S. Matthews. Curr Opin Microbiol. Allostery in the Lac1/ GalR Family: Variations on a Theme. 2009 Apr; 12(2): 129–137</ref>.
+Some common examples of DBDs include:
+*[[Helix-turn-helix|helix-turn-helix]]
+*[[Helix-turn-helix|Helix-turn-helix]][[Zinc finger|zinc finger]]
+*[[Zinc finger|Zinc finger]][[Winged finger|winged helix]]
+*[[Winged finger|Winged finger]][[Helix-loop-helix|helix-loop-helix]],&nbsp;which is&nbsp;present in some [[Transcription factor|transcription factors.]]<br>
+*Leucine Zipper
+*<u></u>Homeodomain
+=== References:  ===
+<references />