DNA binding domain: Difference between revisions
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A [[DNA|DNA]] binding domain (DBD) is part of a [[Protein|protein]] with a high affinity for DNA. For example, [[Transcription factor|transcription factors]]. DBDs have a minimum of one [[Motif|motif]] which can bind to non-sequence specific or sequence specific [[DNA|DNA]]. [[Structural motifs|Structural motifs]] can interact with [[Single stranded binding protein|single stranded and]] [[Double helix|double stranded DNA]]. The functions of DBDs include allowing structural changes to take place to a protein and to allow regulation of [[Transcription|transcription]] | A [[DNA|DNA]] binding domain (DBD) is part of a [[Protein|protein]] with a high affinity for DNA. For example, [[Transcription factor|transcription factors]]. DBDs have a minimum of one [[Motif|motif]] which can bind to non-sequence specific or sequence specific [[DNA|DNA]]. [[Structural motifs|Structural motifs]] can interact with [[Single stranded binding protein|single stranded and]] [[Double helix|double stranded DNA]]. The functions of DBDs include allowing structural changes to take place to a protein and to allow regulation of [[Transcription|transcription]]<ref>L. Swint-Kruse and K. S. Matthews. Curr Opin Microbiol. Allostery in the Lac1/ GalR Family: Variations on a Theme. 2009 Apr; 12(2): 129–137</ref>. | ||
Some common examples of DBDs include: | Some common examples of DBDs include: | ||
*[[Helix-turn-helix|helix-turn-helix]] | |||
*[[Helix-turn-helix|Helix-turn-helix]][[Zinc finger|zinc finger]] | |||
-[[Zinc finger|zinc finger]] | *[[Zinc finger|Zinc finger]][[Winged finger|winged helix]] | ||
*[[Winged finger|Winged finger]][[Helix-loop-helix|helix-loop-helix]], which is present in some [[Transcription factor|transcription factors.]]<br> | |||
*Leucine Zipper | |||
*<u></u>Homeodomain | |||
< | |||
=== References: === | === References: === | ||
<references /> | <references /> | ||
Latest revision as of 10:49, 25 October 2018
A DNA binding domain (DBD) is part of a protein with a high affinity for DNA. For example, transcription factors. DBDs have a minimum of one motif which can bind to non-sequence specific or sequence specific DNA. Structural motifs can interact with single stranded and double stranded DNA. The functions of DBDs include allowing structural changes to take place to a protein and to allow regulation of transcription[1].
Some common examples of DBDs include:
- helix-turn-helix
- Helix-turn-helixzinc finger
- Zinc fingerwinged helix
- Winged fingerhelix-loop-helix, which is present in some transcription factors.
- Leucine Zipper
- Homeodomain
References:
- ↑ L. Swint-Kruse and K. S. Matthews. Curr Opin Microbiol. Allostery in the Lac1/ GalR Family: Variations on a Theme. 2009 Apr; 12(2): 129–137