Troponin: Difference between revisions
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Troponin is thought to be specialised form another calcium ion binding protein, [[Calmodulin|calmodulin]], which is found in smooth muscle. The extra subunits, T and I, mean that the | Troponin is thought to be specialised form another calcium ion binding protein, [[Calmodulin|calmodulin]], which is found in smooth muscle. The extra subunits, T and I, mean that the myosin heds are able to move towards the actin filaments very quickly for rapid contraction, This is needed in [[Skeletal Muscle|skeletal muscle]] for example.<ref>Alberts, B. et al (2008) Molecular Biology of the Cell, 5th ed, Garland Science Taylor and Francis Group, New York, pp. 1028-1030</ref> | ||
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Revision as of 15:07, 29 November 2013
Troponin complexes consist of three subunits - troponin T (also known as TnT or TNNT), troponin I (TnI or TNNI) and troponin C (TnC or TNNC). Troponin is therefore heterotrimeric, with each of the different subunits providing specific binding sites, allowing each troponin to interract with a single molecule of tropomyosin, an actin filament and a Ca2+ ion respectfully. The ability of troponin to bind Ca2+ allows it to undergo a conformational and therefore moves the tropomyosin away from the myosin binding site on actin. This means that the two filaments can form a cross bridge [1].
Troponin is thought to be specialised form another calcium ion binding protein, calmodulin, which is found in smooth muscle. The extra subunits, T and I, mean that the myosin heds are able to move towards the actin filaments very quickly for rapid contraction, This is needed in skeletal muscle for example.[2]