Template strand: Difference between revisions
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DNA Template | DNA Template Strand (also known as the anti-sense strand), is one of the strands of DNA that is present after being unwound by the enzyme [[DNA_helicase|DNA helicase]] during [[DNA_transcription|transcription]] of a gene. Ribonucleotide Triphosphates (rNTPs) then align along the sense anti-sense strand by [[Watson-crick_base_pairing|Watson-Crick base pairing]]. In [[Eukaryotes|eukaryotes]] the ribonucleotides are then joined together by [[RNA_polymerase_II|RNA polymerase II]] (in prokaryotes, this is just [[RNA_polymerase|RNA polymerase]]) to form a [[Pre-mRNA|pre-mRNA]] molecule that is complimentary to the anti-sense strand. Transcription ends when the RNA polymerases reaches a 'stop' codon. In eukaryotes only, [[Rna_splicing|splicing]] will then take place in order to remove any non-coding regions of DNA ([[Introns|introns]]) to give the final [[MRNA|mRNA strand]]. The mRNA then leaves the nucleus through a [[Nuclear_pore|nuclear pore]] and is [[Translation|translated]] by [[Ribosome|ribosomes]] to form a sequence of [[Amino_acids|amino acids]] and thus a protein. <ref>Lodish H., Kaiser CA., Bretscher A., Amon A., Berk A., Krieger M., Ploegh H and Scott MP (2012) Molecular Cell Biology, 7th edition, New York: WH FreemanfckLRpage:124</ref>.<br> | ||
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Revision as of 15:51, 19 October 2018
DNA Template Strand (also known as the anti-sense strand), is one of the strands of DNA that is present after being unwound by the enzyme DNA helicase during transcription of a gene. Ribonucleotide Triphosphates (rNTPs) then align along the sense anti-sense strand by Watson-Crick base pairing. In eukaryotes the ribonucleotides are then joined together by RNA polymerase II (in prokaryotes, this is just RNA polymerase) to form a pre-mRNA molecule that is complimentary to the anti-sense strand. Transcription ends when the RNA polymerases reaches a 'stop' codon. In eukaryotes only, splicing will then take place in order to remove any non-coding regions of DNA (introns) to give the final mRNA strand. The mRNA then leaves the nucleus through a nuclear pore and is translated by ribosomes to form a sequence of amino acids and thus a protein. [1].
References
- ↑ Lodish H., Kaiser CA., Bretscher A., Amon A., Berk A., Krieger M., Ploegh H and Scott MP (2012) Molecular Cell Biology, 7th edition, New York: WH FreemanfckLRpage:124