Troponin: Difference between revisions
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Troponin complexes consist of three subunits - [[ | Troponin complexes consist of three subunits - [[Troponin T|troponin T]] (also known as TnT or TNNT), [[Troponin I|troponin I]] (TnI or TNNI) and [[Troponin C|troponin C]] (TnC or TNNC). Troponin is therefore heterotrimeric, with each of the different subunits providing specific binding sites, allowing each troponin to interract with a single molecule of [[Tropomyosin|tropomyosin]], an [[Actin|actin]] filament and a [[Calcium|Ca<sup>2+</sup>]] [[Ions|ion]] respectfully. The ability of troponin to bind [[Ca2+ ion|Ca2+]] allows it to undergo a conformational and therefore moves the [[Tropomyosin|tropomyosin]] away from the [[Myosin|myosin]] binding site on [[Actin|actin]]. This means that the two filaments can form a cross bridge. | ||
= '''References''' = | |||
<references /><ref>Molecular Biology of the Cell, 4th edition Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, and Peter Walter. 2002.</ref> | |||
Revision as of 20:29, 28 November 2011
Troponin complexes consist of three subunits - troponin T (also known as TnT or TNNT), troponin I (TnI or TNNI) and troponin C (TnC or TNNC). Troponin is therefore heterotrimeric, with each of the different subunits providing specific binding sites, allowing each troponin to interract with a single molecule of tropomyosin, an actin filament and a Ca2+ ion respectfully. The ability of troponin to bind Ca2+ allows it to undergo a conformational and therefore moves the tropomyosin away from the myosin binding site on actin. This means that the two filaments can form a cross bridge.
References
- ↑ Molecular Biology of the Cell, 4th edition Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, and Peter Walter. 2002.