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SERCA&nbsp;is the abbreviation for the [[Sarcoplasmic_reticulum|sarco]]/[[endoplasmic reticulum|endoplasmic reticulum]] [[calcium|Ca<sup>2+</sup>]] [[ATPase|ATPase]]&nbsp;pump. It pumps [[calcium|calcium]] ions into the&nbsp;[[Sacroplasmic reticulum|sarcoplasmic reticulum&nbsp;as]] well as in the [[Endoplasmic reticulum|endoplasmic reticulum]]<ref>Heldin, C. and Purton M. (1996) Signal Transduction, 1st edition, London: Chapman and Hall. pp 211</ref>. It is a regulator of the [[OFF mechanism|OFF&nbsp;mechanisms]] designed to keep our intracellular calcium ion concentration low<ref>Heldin, C. and Purton M. (1996) Signal Transduction, 1st edition, London: Chapman and Hall. pp 210</ref>. SERCA&nbsp;pumps are located on the [[membrane|membrane]], they eventually get saturated along with the [[PMCA|PMCA]]&nbsp;pumps by a rising level of calcium ions, and then only do the [[Mitochondria|mitochondria]]&nbsp;and [[Na/Ca exchanger|Na/Ca exchanger]]&nbsp;begin to work.&nbsp;<br>  
SERCA&nbsp;is the abbreviation for the [[Sarcoplasmic reticulum|sarco]]/[[Endoplasmic reticulum|endoplasmic reticulum]] [[Calcium|Ca<sup>2+</sup>]] [[ATPase|ATPase]]&nbsp;pump. It pumps [[Calcium|calcium]] ions into the&nbsp;[[Sacroplasmic reticulum|sarcoplasmic reticulum&nbsp;as]] well as in the [[Endoplasmic reticulum|endoplasmic reticulum]]<ref>Heldin, C. and Purton M. (1996) Signal Transduction, 1st edition, London: Chapman and Hall. pp 211</ref>. It is a regulator of the [[OFF mechanism|OFF&nbsp;mechanisms]] designed to keep our intracellular calcium ion concentration low<ref>Heldin, C. and Purton M. (1996) Signal Transduction, 1st edition, London: Chapman and Hall. pp 210</ref>. SERCA&nbsp;pumps are located on the [[Membrane|membrane]], they eventually get saturated along with the [[PMCA|PMCA]]&nbsp;pumps by a rising level of calcium ions, and then only do the [[Mitochondria|mitochondria]]&nbsp;and [[Na/Ca exchanger|Na/Ca exchanger]]&nbsp;begin to work.&nbsp;<br>  


== Inhibitors  ==
== Inhibitors  ==


SERCA&nbsp;pumps are inhibited by more than 72 compounds<ref>http://www.sciencedirect.com/science/article/pii/S0223523411000912</ref>, however, the most commonly used ones are [[thapsigargin|thapsigargin]]<ref>http://onlinelibrary.wiley.com/doi/10.1046/j.1471-4159.2003.01962.x/full</ref>, [[2,5-Di(tert-butyl)-1,4-benzohydroquinone|2,5-Di(tert-butyl)-1,4-benzohydroquinone]]<ref>http://www.sciencedirect.com/science/article/pii/S0223523411000912</ref> and [[cyclopiazonic acid|cyclopiazonic acid]]<ref>http://www.jbc.org/content/282/13/9748.abstract</ref>.<br>  
SERCA&nbsp;pumps are inhibited by more than 72 compounds<ref>Elam C, Lape M, Deye J, Zultowsky J, Stanton D, Paula S. Discovery of novel SERCA inhibitors by virtual screening of a large compound library. European Journal of Medicinal Chemistry. 2011;46(5):1512-1523.</ref>, however, the most commonly used ones are [[Thapsigargin|thapsigargin]]<ref>http://onlinelibrary.wiley.com/doi/10.1046/j.1471-4159.2003.01962.x/full</ref>, [[2,5-Di(tert-butyl)-1,4-benzohydroquinone|2,5-Di(tert-butyl)-1,4-benzohydroquinone]]<ref>http://www.sciencedirect.com/science/article/pii/S0223523411000912</ref> and [[Cyclopiazonic acid|cyclopiazonic acid]]<ref>http://www.jbc.org/content/282/13/9748.abstract</ref>.<br>  


== References  ==
== References  ==


<references />
<references />

Revision as of 02:33, 4 December 2017

SERCA is the abbreviation for the sarco/endoplasmic reticulum Ca2+ ATPase pump. It pumps calcium ions into the sarcoplasmic reticulum as well as in the endoplasmic reticulum[1]. It is a regulator of the OFF mechanisms designed to keep our intracellular calcium ion concentration low[2]. SERCA pumps are located on the membrane, they eventually get saturated along with the PMCA pumps by a rising level of calcium ions, and then only do the mitochondria and Na/Ca exchanger begin to work. 

Inhibitors

SERCA pumps are inhibited by more than 72 compounds[3], however, the most commonly used ones are thapsigargin[4], 2,5-Di(tert-butyl)-1,4-benzohydroquinone[5] and cyclopiazonic acid[6].

References

  1. ↑ Heldin, C. and Purton M. (1996) Signal Transduction, 1st edition, London: Chapman and Hall. pp 211
  2. ↑ Heldin, C. and Purton M. (1996) Signal Transduction, 1st edition, London: Chapman and Hall. pp 210
  3. ↑ Elam C, Lape M, Deye J, Zultowsky J, Stanton D, Paula S. Discovery of novel SERCA inhibitors by virtual screening of a large compound library. European Journal of Medicinal Chemistry. 2011;46(5):1512-1523.
  4. ↑ http://onlinelibrary.wiley.com/doi/10.1046/j.1471-4159.2003.01962.x/full
  5. ↑ http://www.sciencedirect.com/science/article/pii/S0223523411000912
  6. ↑ http://www.jbc.org/content/282/13/9748.abstract
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