SERCA is the abbreviation for the sarco/endoplasmic reticulum Ca2+ ATPase pump. It pumps calcium ions into the sarcoplasmic reticulum as well as in the endoplasmic reticulum. It is a regulator of the OFF mechanisms designed to keep our intracellular calcium ion concentration low. SERCA pumps are located on the membrane, they eventually get saturated along with the PMCA pumps by a rising level of calcium ions, and then only do the mitochondria and Na/Ca exchanger begin to work.
- ↑ Heldin, C. and Purton M. (1996) Signal Transduction, 1st edition, London: Chapman and Hall. pp 211
- ↑ Heldin, C. and Purton M. (1996) Signal Transduction, 1st edition, London: Chapman and Hall. pp 210
- ↑ Elam C, Lape M, Deye J, Zultowsky J, Stanton D, Paula S. Discovery of novel SERCA inhibitors by virtual screening of a large compound library. European Journal of Medicinal Chemistry. 2011;46(5):1512-1523.
- ↑ Watson W, Facchina S, Grimaldi M, Verma A. Sarco-endoplasmic reticulum Ca2+ ATPase (SERCA) inhibitors identify a novel calcium pool in the central nervous system. Journal of Neurochemistry. 2003;87(1):30-43.
- ↑ http://www.sciencedirect.com/science/article/pii/S0223523411000912
- ↑ Moncoq K, Trieber C, Young H. The Molecular Basis for Cyclopiazonic Acid Inhibition of the Sarcoplasmic Reticulum Calcium Pump. Journal of Biological Chemistry. 2007;282(13):9748-9757.