RNA Polymerase: Difference between revisions
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*[[RNA polymerase III|RNA_polymerase_III]]: Involved in the transcription of transfer RNA ([[TRNA|tRNA]])<br><u></u> | *[[RNA polymerase III|RNA_polymerase_III]]: Involved in the transcription of transfer RNA ([[TRNA|tRNA]])<br><u></u> | ||
All three of the above RNA Polymerases' have a conserved core. This means that | All three of the above RNA Polymerases' have a conserved core. This means that, in the case of RNA Polymerase II and III transcription can be initiated by the promoter sequence (varying TATA - box sequences) of the other RNA Polymerase. This leads to a varying level of polymerase specificity, depending on the other promoter sequence and transcription conditions.<ref name="RNA Polymerase conservation">http://www.jbc.org/content/289/29/20396.abstract RNA Polymerase III Accurately Initiates Transcription from RNA Polymerase II Promoters in Vitro. Author: Sascha H. C. Duttke</ref> | ||
=== References === | === References === | ||
<references /><br><references /> | <references /><br><references /> | ||
Latest revision as of 12:25, 26 November 2014
RNA Polymerases are enzymes involved in the production of RNA. After the annealing of a primer, RNA polymerases build a complementary strand of RNA from free nucleotides using a strand of DNA as a template. The active form is a complex consisting of multiple subunits known as the RNA polymerase holoenzyme (Molecular mass ~400 kilodaltons) [1].
In Eukaryotes some RNA polymerases include:
- RNA_polymerase_I: Involved in the transcription of ribosomal RNA.
- RNA_polymerase_II: Transcribes all genes that code for proteins.
- RNA_polymerase_III: Involved in the transcription of transfer RNA (tRNA)
All three of the above RNA Polymerases' have a conserved core. This means that, in the case of RNA Polymerase II and III transcription can be initiated by the promoter sequence (varying TATA - box sequences) of the other RNA Polymerase. This leads to a varying level of polymerase specificity, depending on the other promoter sequence and transcription conditions.[2]
References
- ↑ Hartl. D, Jones. E (2009), Genetics - Analysis Of Genes And Genomes, 7th Edition, Sudbury: Jones and Bartlett Publishers p346
- ↑ http://www.jbc.org/content/289/29/20396.abstract RNA Polymerase III Accurately Initiates Transcription from RNA Polymerase II Promoters in Vitro. Author: Sascha H. C. Duttke