Protein kinase A: Difference between revisions
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Protein Kinase A (PKA) is a [[Proteins|protein]] that is dependent on [[CAMP|cyclic AMP]] ([[CAMP|CAMP]]) and without it, is deactivated. PKA is involved in [[Signal-transduction pathway|signal-transduction pathways]] and [[Phosphorylation|phosphorylates]] [[Proteins|proteins]] by adding a [[Phosphate group|phosphate group]]. The [[Molecule|molecule]] consists of two subunits, a regulatory subunit and a calalytic subunit <ref>Berg J., | Protein Kinase A (PKA) is a [[Proteins|protein]] that is dependent on [[CAMP|cyclic AMP]] ([[CAMP|CAMP]]) and without it, is deactivated. PKA is involved in [[Signal-transduction pathway|signal-transduction pathways]] and [[Phosphorylation|phosphorylates]] [[Proteins|proteins]] by adding a [[Phosphate group|phosphate group]]. The [[Molecule|molecule]] consists of two subunits, a regulatory subunit and a calalytic subunit <ref>Berg, J. Tymoczko, J. and Stryer, L. (2007) Biochemistry, 6th edition, New York: WH Freeman</ref>. These subunits are inactive when [[CAMP|cAMP]] is not bound. When [[CAMP|cAMP]] binds to a regulatory subunit a conformational change occurs. This change means that the catalytic subunit becomes active and is no longer inhibited. This means that the protein can now [[Phosphorylation|phosphorylate]] other [[Proteins|proteins]] by removing a phosphate from [[ATP]], and adding it to a [[Serine|serine]] residue on the target [[Protein|protein]] which in turn leads to a cellular response. | ||
=== References === | === References === | ||
<references /><br> | <references /><br> | ||
Revision as of 17:06, 21 November 2010
Protein Kinase A (PKA) is a protein that is dependent on cyclic AMP (CAMP) and without it, is deactivated. PKA is involved in signal-transduction pathways and phosphorylates proteins by adding a phosphate group. The molecule consists of two subunits, a regulatory subunit and a calalytic subunit [1]. These subunits are inactive when cAMP is not bound. When cAMP binds to a regulatory subunit a conformational change occurs. This change means that the catalytic subunit becomes active and is no longer inhibited. This means that the protein can now phosphorylate other proteins by removing a phosphate from ATP, and adding it to a serine residue on the target protein which in turn leads to a cellular response.
References
- ↑ Berg, J. Tymoczko, J. and Stryer, L. (2007) Biochemistry, 6th edition, New York: WH Freeman