Chargaff's rule: Difference between revisions
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It is proven that [[DNA|DNA]] is a right-handed double helix structure by [[James_Watson|Watson]] and [[Francis_Crick|Crick]]. Another biochemist [[Erwin_Chargaff|Erwin Chargaff]] observed a relationship between the molarity of the four different bases. A bracket [ ] will be used to denote the molarity of the bases. Firstly, he noticed that the concentration of [[adenine|adenine]] is always equal to [[thymine|thymine]], [A] = [T]. Secondly, the concentration of [[guanine|guanine]] is always equal to [[cytosine|cytosine]] [G]=[C]. Thirdly, the concentration of [[purine|purine]] (A and G) are always equal to [[pyrimidine|pyrimidine]] (T and C). Hence, [A] + [G] = [C] + [T]. These are known as Chargaff's rules<ref>(1) Daniel L.Hartl, Maryellen Ruvolo. Genetics analysis of genes and genomes. Eight edition. USA. Jones and Bartlett Learning. 2012</ref>.<br> | |||
=== References === | |||
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Latest revision as of 17:39, 18 October 2018
It is proven that DNA is a right-handed double helix structure by Watson and Crick. Another biochemist Erwin Chargaff observed a relationship between the molarity of the four different bases. A bracket [ ] will be used to denote the molarity of the bases. Firstly, he noticed that the concentration of adenine is always equal to thymine, [A] = [T]. Secondly, the concentration of guanine is always equal to cytosine [G]=[C]. Thirdly, the concentration of purine (A and G) are always equal to pyrimidine (T and C). Hence, [A] + [G] = [C] + [T]. These are known as Chargaff's rules[1].
References
- ↑ (1) Daniel L.Hartl, Maryellen Ruvolo. Genetics analysis of genes and genomes. Eight edition. USA. Jones and Bartlett Learning. 2012