Glut 4: Difference between revisions
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Glut4 is a member of the Solute Carrier Family 2 (SLCA2). The [[Protein|protein]] is encoded by the SLC2A4 gene and is involved in the [[Insulin|insulin]]-dependent trafficking of [[Glucose|glucose]] to the [[Plasma membrane|plasma membrane<ref>James, DE. et al. Nature 1988 333:183-185</ref>]]. The protein is crucial to [[Glucose|glucose]] transport and [[Genetic mutation|genetic mutations]] can be involved in Non-Insulin Dependent Diabetes Mellitus ([[Diabetes|Diabetes]]) <ref>Bogen JS Aug 2010 http://www.ncbi.nlm.nih.gov/pubmed/20417083</ref>. Glut4 is typically found in skeletal and cardiac muscle, as well as adipose tissue. | Glut4 is a member of the Solute Carrier Family 2 (SLCA2). The [[Protein|protein]] is encoded by the SLC2A4 gene and is involved in the [[Insulin|insulin]]-dependent trafficking of [[Glucose|glucose]] to the [[Plasma membrane|plasma membrane<ref>James, DE. et al. Nature 1988 333: 183-185</ref>]]. The protein is crucial to [[Glucose|glucose]] transport and [[Genetic mutation|genetic mutations]] can be involved in Non-Insulin Dependent Diabetes Mellitus ([[Diabetes|Diabetes]]) <ref>Bogen JS Aug 2010 http://www.ncbi.nlm.nih.gov/pubmed/20417083</ref>. Glut4 is typically found in skeletal and cardiac muscle, as well as adipose tissue. | ||
In Diabetes, Glut4 mRNA and protein levels decreases in both white and brown [[Adipose tissue|adipose tissue]]. <ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1130854/</ref> | In Diabetes, Glut4 mRNA and protein levels decreases in both white and brown [[Adipose tissue|adipose tissue]]. <ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1130854/</ref> | ||
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=== References'''<br>''' === | === References'''<br>''' === | ||
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Revision as of 11:35, 23 October 2018
Glut4 is a member of the Solute Carrier Family 2 (SLCA2). The protein is encoded by the SLC2A4 gene and is involved in the insulin-dependent trafficking of glucose to the plasma membrane[1]. The protein is crucial to glucose transport and genetic mutations can be involved in Non-Insulin Dependent Diabetes Mellitus (Diabetes) [2]. Glut4 is typically found in skeletal and cardiac muscle, as well as adipose tissue.
In Diabetes, Glut4 mRNA and protein levels decreases in both white and brown adipose tissue. [3]
Also see Glut transporter.
References
- ↑ James, DE. et al. Nature 1988 333: 183-185
- ↑ Bogen JS Aug 2010 http://www.ncbi.nlm.nih.gov/pubmed/20417083
- ↑ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1130854/