Genetic mutation

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Genetic mutation- this term indicates an alteration to base sequence in DNA of an organism which results in a mutant allele of a gene i.e. an allele that occurs in less than 1% of population. The change is heritable and can be passed on to offspring if fixed into the parental genome. Mutations can vary depending on the type of genomic alteration:

To investigate the events leading to mutation we can look at the 3 types of mutagenesis process:

We can calculate the rate of mutation occurance using an equation from Poisson distribution:

P0=e-mN

where P0 is the probability of seeing no mutations, N is the number of cells per culture and m is the mutation rate [1][2].

References

  1. Genetics, 1987, Geoffrey Zubay
  2. Encyclopedia of Genetics,Volume 3, 2002, S.Brenner,J.H. Miller


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