SERCA: Difference between revisions
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SERCA is the abbreviation for the [[Sarcoplasmic_reticulum|sarco]]/[[endoplasmic reticulum|endoplasmic reticulum]] [[calcium|Ca<sup>2+</sup>]] [[ATPase|ATPase]] pump. It pumps [[calcium|calcium]] ions into the [[Sacroplasmic reticulum|sarcoplasmic reticulum as]] well as in the [[Endoplasmic reticulum|endoplasmic reticulum]]<ref>Heldin, C. and Purton M. (1996) Signal Transduction, 1st edition, London: Chapman and Hall. pp 211</ref>. It is a regulator of the [[OFF mechanism|OFF mechanisms]] designed to keep our intracellular calcium ion concentration low<ref>Heldin, C. and Purton M. (1996) Signal Transduction, 1st edition, London: Chapman and Hall. pp 210</ref>. SERCA pumps are located on the [[membrane|membrane]], they eventually get saturated along with the [[PMCA|PMCA]] pumps by a rising level of calcium ions, and then only do the [[Mitochondria|mitochondria]] and [[Na/Ca exchanger|Na/Ca exchanger]] begin to work. <br> | |||
SERCA is the abbreviation for the sarco/endoplasmic reticulum Ca+ | |||
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== Inhibitors == | == Inhibitors == | ||
SERCA pumps are inhibited by more than 72 compounds<ref>http://www.sciencedirect.com/science/article/pii/S0223523411000912</ref>, however, the most commonly used ones are thapsigargin<ref>http://onlinelibrary.wiley.com/doi/10.1046/j.1471-4159.2003.01962.x/full</ref>, 2,5-Di(tert-butyl)-1,4-benzohydroquinone<ref>http://www.sciencedirect.com/science/article/pii/S0223523411000912</ref> and | SERCA pumps are inhibited by more than 72 compounds<ref>http://www.sciencedirect.com/science/article/pii/S0223523411000912</ref>, however, the most commonly used ones are [[thapsigargin|thapsigargin]]<ref>http://onlinelibrary.wiley.com/doi/10.1046/j.1471-4159.2003.01962.x/full</ref>, [[2,5-Di(tert-butyl)-1,4-benzohydroquinone|2,5-Di(tert-butyl)-1,4-benzohydroquinone]]<ref>http://www.sciencedirect.com/science/article/pii/S0223523411000912</ref> and [[cyclopiazonic acid|cyclopiazonic acid]]<ref>http://www.jbc.org/content/282/13/9748.abstract</ref>.<br> | ||
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== References == | == References == | ||
<references /> | <references /> | ||
Revision as of 18:39, 29 November 2011
SERCA is the abbreviation for the sarco/endoplasmic reticulum Ca2+ ATPase pump. It pumps calcium ions into the sarcoplasmic reticulum as well as in the endoplasmic reticulum[1]. It is a regulator of the OFF mechanisms designed to keep our intracellular calcium ion concentration low[2]. SERCA pumps are located on the membrane, they eventually get saturated along with the PMCA pumps by a rising level of calcium ions, and then only do the mitochondria and Na/Ca exchanger begin to work.
Inhibitors
SERCA pumps are inhibited by more than 72 compounds[3], however, the most commonly used ones are thapsigargin[4], 2,5-Di(tert-butyl)-1,4-benzohydroquinone[5] and cyclopiazonic acid[6].
References
- ↑ Heldin, C. and Purton M. (1996) Signal Transduction, 1st edition, London: Chapman and Hall. pp 211
- ↑ Heldin, C. and Purton M. (1996) Signal Transduction, 1st edition, London: Chapman and Hall. pp 210
- ↑ http://www.sciencedirect.com/science/article/pii/S0223523411000912
- ↑ http://onlinelibrary.wiley.com/doi/10.1046/j.1471-4159.2003.01962.x/full
- ↑ http://www.sciencedirect.com/science/article/pii/S0223523411000912
- ↑ http://www.jbc.org/content/282/13/9748.abstract