Genetic mutation: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
'''Genetic mutation- '''this term indicates an alteration to base sequence in [[DNA|DNA]] of an organism which results in a mutant [[Allele|allele]] of a [[Gene|gene]] i.e. an allele that occurs in less than 1% of population.The change is heritable and can be passed on to offspring if fixed into the parental [[Genome|genome]]. Mutations can vary depending on the type of genomic alteration: | '''Genetic mutation- '''this term indicates an alteration to base sequence in [[DNA|DNA]] of an organism which results in a mutant [[Allele|allele]] of a [[Gene|gene]] i.e. an allele that occurs in less than 1% of population.The change is heritable and can be passed on to offspring if fixed into the parental [[Genome|genome]]. Mutations can vary depending on the type of genomic alteration: | ||
*addition | *addition | ||
*deletion | *deletion | ||
*substitution | *substitution | ||
*rearrangement of bases. | *rearrangement of bases. | ||
To investigate the events leading to mutation we can look at mutagenesis process. There are three types: | To investigate the events leading to mutation we can look at mutagenesis process. There are three types: | ||
*spontaneous (no mutation causing agent) | *spontaneous (no mutation causing agent) | ||
*induced (a foreign genome introduced e.g.in the laboratory) | *induced (a foreign genome introduced e.g.in the laboratory) | ||
*directed (in vitro change to genome).<br> | *directed (in vitro change to genome).<br> | ||
| Line 17: | Line 17: | ||
where P<sub>0</sub> is the probability of seeing no mutations, N is the number of cells per culture and m is the mutation rate <ref>Genetics, 1987, Geoffrey Zubay</ref><ref>Encyclopedia of Genetics,Volume 3, 2002, S.Brenner,J.H. Miller</ref>.<br> | where P<sub>0</sub> is the probability of seeing no mutations, N is the number of cells per culture and m is the mutation rate <ref>Genetics, 1987, Geoffrey Zubay</ref><ref>Encyclopedia of Genetics,Volume 3, 2002, S.Brenner,J.H. Miller</ref>.<br> | ||
<references /><br> | === References === | ||
<references /><br> | |||
<br> | <br> | ||
Revision as of 07:20, 25 November 2012
Genetic mutation- this term indicates an alteration to base sequence in DNA of an organism which results in a mutant allele of a gene i.e. an allele that occurs in less than 1% of population.The change is heritable and can be passed on to offspring if fixed into the parental genome. Mutations can vary depending on the type of genomic alteration:
- addition
- deletion
- substitution
- rearrangement of bases.
To investigate the events leading to mutation we can look at mutagenesis process. There are three types:
- spontaneous (no mutation causing agent)
- induced (a foreign genome introduced e.g.in the laboratory)
- directed (in vitro change to genome).
We can calculate the rate of mutation occurance using an equation from Poisson distribution:
P0=e-mN
where P0 is the probability of seeing no mutations, N is the number of cells per culture and m is the mutation rate [1][2].
References