Phosphorylation cascade: Difference between revisions
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A phosphorylation cascade is organised from many signalling [[proteins|proteins]] controlled by [[kinase|kinases]]. A protein kinase is activated by [[phosphorylation|phosphorylation]] which in turn phosphorylates the next protein kinase in a sequence and so on. As the signal is carried onwards it is amplified and sometimes can spread to other signalling pathways <ref>Page 929. Alberts, B., Johnson, A., Lewis, J., Raff, M.,Roberts, K., and Watson, J. (2007) Molecular Biology of the Cell, 5th edition, Garland</ref>. An example of a phosphorylation cascade is triggered by [[RAS|RAS]]; a [[MAP Kinase|MAP Kinase]] signalling molecule. Once activated it relays a signal downstream by phosphorylating the protein kinases [[Raf|Raf]], [[Mek|Mek]] and [[Erk|Erk]]. Raf recieves a signal directly from RAS which in turn phosphorylates and activates Mek, the phosphorylation of Mek can then activate the final kinase in the series Erk <ref>Page 896. Alberts, B., Johnson, A., Lewis, J., Raff, M.,Roberts, K., and Watson, J. (2007) Molecular Biology of the Cell, 5th edition, Garland.</ref>. | |||
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Latest revision as of 19:42, 27 November 2012
A phosphorylation cascade is organised from many signalling proteins controlled by kinases. A protein kinase is activated by phosphorylation which in turn phosphorylates the next protein kinase in a sequence and so on. As the signal is carried onwards it is amplified and sometimes can spread to other signalling pathways [1]. An example of a phosphorylation cascade is triggered by RAS; a MAP Kinase signalling molecule. Once activated it relays a signal downstream by phosphorylating the protein kinases Raf, Mek and Erk. Raf recieves a signal directly from RAS which in turn phosphorylates and activates Mek, the phosphorylation of Mek can then activate the final kinase in the series Erk [2].
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