DNA binding domain

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A DNA binding domain (DBD) is part of a protein with a high affinity for DNA. For example, transcription factors. DBDs have a minimum of one motif which can bind to non-sequence specific or sequence specific DNA. Structural motifs can interact with single stranded and double stranded DNA. The functions of DBDs include allowing structural changes to take place to a protein and to allow regulation of transcription.[1]

Some common examples of DBDs include:

-helix-turn-helix

-zinc finger

-winged helix

-helix-loop-helix, which is present in some transcription factors.


References:

  1. ↑ L. Swint-Kruse and K. S. Matthews. Curr Opin Microbiol. Allostery in the Lac1/ GalR Family: Variations on a Theme. 2009 Apr; 12(2): 129–137
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