Glut 4
Glut4 is a member of the Solute Carrier Family 2 (SLCA2). The protein is encoded by the SLC2A4 gene and is involved in the insulin-dependent trafficking of glucose to the plasma membrane[1]. The protein is crucial to glucose transport and genetic mutations can be involved in Non-Insulin Dependent Diabetes Mellitus (Diabetes) [2]. Glut4 is typically found in skeletal and cardiac muscle, as well as adipose tissue.
In Diabetes, Glut4 mRNA and protein levels decreases in both white and brown adipose tissue. [3]
Also see Glut transporter.
References
- ↑ James, DE. et al. Nature 1988 333:183-185
- ↑ Bogen JS Aug 2010 http://www.ncbi.nlm.nih.gov/pubmed/20417083
- ↑ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1130854/