Introns
Introns are non-coding sequences of DNA found between coding sections known as exons in eukaryotic genes and in rare cases in some prokaryotic cells [1].
Introns are removed by splicing by the spliceosome and other associated proteins that are recruited in the process of forming mature mRNA from pre-mRNA [2].
Introns nearly always have a consensus sequence that begins with GU and ends with AG which is preceeeded by a pyrimidine rich tract that acts as a signal for splicing. [3]
References
- ↑ Khan AU, Ajamaluddin M, Ahmad M.(2001 Oct) A unique group of self-splicing introns in bacteriophage T4. Indian J Biochem Biophys. 38(5):289-93.
- ↑ Hogg R, McGrail JC, O'Keefe RT.(Aug 2010) The function of the NineTeen Complex (NTC) in regulating spliceosome conformations and fidelity during pre-mRNA splicing. Biochem Soc Trans. 38(4):1110-5.
- ↑ Berg, J., Tymoczko, J. and Stryer, L. 2012. Biochemistry. Basingstoke: W. H. Freeman. P136