SERCA
SERCA
SERCA is the abbreviation for the sarco/endoplasmic reticulum Ca++ ATPase pump. It pumps calcium ions into the sarcoplasmic reticulum as well as in the endoplasmic reticulum[1]. It is a regulator of the OFF mechanisms designed to keep our intracellular calcium ion concentration low[2]. SERCA pumps are located on the membrane, they eventually get saturated along with the PMCA pumps by a rising level of calcium ions, and then only do the mitochondria and Na/Ca exchanger begin to work.
Inhibitors
SERCA pumps are inhibited by more than 72 compounds[3], however, the most commonly used ones are thapsigargin[4], 2,5-Di(tert-butyl)-1,4-benzohydroquinone[5] and Cyclopiazonic acid[6].
References
- ↑ Heldin, C. and Purton M. (1996) Signal Transduction, 1st edition, London: Chapman and Hall. pp 211
- ↑ Heldin, C. and Purton M. (1996) Signal Transduction, 1st edition, London: Chapman and Hall. pp 210
- ↑ http://www.sciencedirect.com/science/article/pii/S0223523411000912
- ↑ http://onlinelibrary.wiley.com/doi/10.1046/j.1471-4159.2003.01962.x/full
- ↑ http://www.sciencedirect.com/science/article/pii/S0223523411000912
- ↑ http://www.jbc.org/content/282/13/9748.abstract