Α-Ketoglutarate

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Alpha Ketoglutarate is a Keto acid produced by the deamination of Glutamate, a reaction that occurs during the Krebs cycle. Alpha Ketoglutarate is an important intermediate in the Krebs Cycle and is produced in the cycle just prior to Succinyl CoA. A key function of Alpha Ketoglutarate is to combine with Nitrogen, eliminating the prospect of nitrogen overload. Through this ability, Alpha Ketoglutarate has an important function to detoxify ammonia present in the brain. Alpha Ketoglutarate also functions as an antioxidant and decreases levels of hydrogen peroxide in the body[1].

References

  1. Long, L; Halliwell, B (2011). "Artefacts in cell culture: α-Ketoglutarate can scavenge hydrogen peroxide generated by ascorbate and epigallocatechin gallate in cell culture media.". Biochemical and biophysical research communications 406 (1): 20–24. doi:10.1016/j.bbrc.2011.01.091.
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