Cytotoxic T-cells

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Cytotoxic T cells are able to search the intracellular compartments to remove or destroy any foreign objects such as bacteria and pathogens which have the potential to cause harm. Also known as a killer T-cell or CD8+ T cells. These cells kill host cells that have become infected by some sort of intracellular pathogen[1].

The cytotoxic T-cells can trigger an endogenous pathway within the target cell leading to apoptosis. This is due to the cytotoxic T-cells releasing "preformed effector molecules"[2][3].

Cytotoxic T-cells contain the CD8+ receptor. They are responsible for binding MHC class I present in most cells, which presents the foreign antigen of the endogenous origin[4].

References

  1. alberts, B (2008). molecular biology of the cell. USA: garland science. glossary
  2. Janeway CA Jr, et al.;2001
  3. Janeway C. Immunobiology. 5th ed. Paris: De Boeck; 2003.
  4. https://www.ncbi.nlm.nih.gov/books/NBK27101/
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