Papain

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It is a cysteine hydrolase that is stable and active under a awide range of conditions. It is very stable even at elevated temperatures [1]. The latex of Carica papaya is a rich source of four cysteine endopeptidases including papain, chymopapain, glycyl endopeptidase, and caricain. The proteins are synthesized as inactive precursors that become active with two minutes of the plant being wounded and the latex expelled. Papain is a minor constituent, but has been more widely studied because it is more easily purified [2].

Contents

Molecular Weight:

Active site residies:

Applications:

References

  1. Cohen, L., Coghlan, V and Dihel, L. (1986) Cloning and Sequencing of papain-encoding cDna, Gene 48, 219, 1986
  2. Akahane, K. and Umeyama,H. (1986) Binding Specificity of Papain and Cathepepsin B, Emzyme 36, 141
  3. Drenth, J., Jansonius, J. Koekoek,R., Swen, H., and Wolters, B.(1968) Structure of Papain, Nature 218, 929


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