Splitting stage

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The splitting stage is the second phase in the process of glycolysis. This involves the actual splitting of a molecule of fructose-1,6-bisphosphate (a 6 carbonmolecule), produced from the Investment Stage of glycolysis, to two 3 carbon molecules. These molecules are named glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. This catabolic reaction occurs in the presence of an enzyme or catalyst named aldose [1]. Two interchangeable, 3 carbon molecules are formed which exist in an equilibrium. The equilibrium lies towards the ketose (sugar containing a ketone), the dihydroxyacetone phosphate, however the equilibrium can readily be shifted to produce the dldose (sugar containing an aldehyde), the glyceraldehyde-3-phosphate. This occurs easily because the aldoseis actually being used up in the Yield Stage to eventually generate Pyruvate [2].


  1. Berg JM, Tymoczko JL, Stryder L. (2002) Biochemistry 5th edn. New York: W H Freeman. Section 16.1
  2. Available online: (http://www.science.marshall.edu/frost/chapter14.pdf) [Accessed 27/11/14]

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