TFIIF

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TFIIF is a eukaryotic transcription factor often found associated with RNA polymerase II. It plays a role in the formation of the Pre-Initiation complex (PIC) prior to the initiation of gene transcription. Allthough eukaryotic transcription initiation is more complex than in bacteria the function of the corresponding transcription factors can be compared. Parts of TFIIF share structural homology with sigma factor in bacteria [1].

References

  1. 1.0 1.1 Alberts, Johnson, Lewis, Raff, Roberts, Walter. (2008) Molecular Biology of The Cell. 5th Edition. p340-1
  2. Whitehall S. (2011) CMB2002 lecture slides
  3. Alberts, Johnson, Lewis, Raff, Roberts, Walter. (2008) Molecular Biology of The Cell. 5th Edition. p340-1
  4. Bernecky C, Grob P, Ebmeier CC, Nogales E, Taatjes DJ. (2011) 'Molecular architecture of the human Mediator-RNA polymerase II-TFIIF assembly' PLoS Biol. 2011 Mar;9(3):e1000603
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