Diacylglycerol: Difference between revisions
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Diacylglycerol (DAG) is molecule which is bound to the inner layer of the phoslipid bilayer in eukaryotic cells by two transmembrane fatty acid tails. DAG is activated when the [[Inositol-Phospholipid signalling pathway|IP (Inositol-Phospholipid) signalling pathway ]] | Diacylglycerol (DAG) is molecule which is bound to the inner layer of the phoslipid bilayer in eukaryotic cells by two transmembrane fatty acid tails. DAG is activated when the [[Inositol-Phospholipid signalling pathway|IP (Inositol-Phospholipid) signalling pathway is]] activated by a [[GPCR|GPCR (G Protein Coupled Recptor) binding]]. The PI pathway activates [[Phospholipase C|PLC-β (phospholipase C)]] which catalyses the reaction whereby [[Phosphatidylinositol 4,5-bisphosphate|PIP<sub>2</sub> (phosphotitylinositol-4,5-bisphosphate)]] is cleaved to form the free [[Molecule|molecule]] [[Inositol 1,4,5 trisphosphate|IP<sub>3</sub> (Inositol-1,4,5-trisphosphate)]] and DAG. From this DAG is then able to interact further in the cell signalling pathway by activating [[Protein kinase C|PKC (Ca2+ dependent Protein Kinase]]), which is a [[Kinase|kinase]] involved in an intercellular [[Phosphorylation|phosphorylation]] cascade <ref>Molecular biology of the cell / Bruce Alberts et al,5th ed,New York : Garland Science, c2008.</ref>.<br> | ||
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Latest revision as of 16:18, 19 November 2010
Diacylglycerol (DAG) is molecule which is bound to the inner layer of the phoslipid bilayer in eukaryotic cells by two transmembrane fatty acid tails. DAG is activated when the IP (Inositol-Phospholipid) signalling pathway is activated by a GPCR (G Protein Coupled Recptor) binding. The PI pathway activates PLC-β (phospholipase C) which catalyses the reaction whereby PIP2 (phosphotitylinositol-4,5-bisphosphate) is cleaved to form the free molecule IP3 (Inositol-1,4,5-trisphosphate) and DAG. From this DAG is then able to interact further in the cell signalling pathway by activating PKC (Ca2+ dependent Protein Kinase), which is a kinase involved in an intercellular phosphorylation cascade [1].
References:
- ↑ Molecular biology of the cell / Bruce Alberts et al,5th ed,New York : Garland Science, c2008.