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A microtubule [[Motor protein|motor protein]] first discovered in the giant [[Axon|axon]] of the quid, kinesins hydrolyse [[ATP|ATP]] to produce energy to move membrane-bound [[Organelles|organelles]] along microtubules. Kinesins carry the membrane-bound organelles away from the neuronal cell body and towards the [[Axon terminal|axon terminal]]. If mutations occur in kinesins can lead to disorders in the nervous system[2].This movement is towards the positive end of the microtubule unlike [[Dyneins|dyneins]], another type of [[Microtubules|microtubule]] motor protein which carry membrane bound organelles towards the negative end of microtubules [1].  
A microtubule [[Motor protein|motor protein]] first discovered in the giant [[Axon|axon]] of the quid, kinesins hydrolyse [[ATP|ATP]] to produce energy to move membrane-bound [[Organelles|organelles]] along microtubules. Kinesins carry the membrane-bound organelles away from the neuronal cell body and towards the [[Axon terminal|axon terminal]]. If [[Mutations|mutations]] occur in kinesins can lead to disorders in the [[Nervous system|nervous system]]<ref>Berg JM, Tymoczko JL, Stryer L. Biochemistry. 5th edition. New York: W H Freeman; 2002. Section 34.3, Kinesin and Dynein Move Along Microtubules.</ref>. This movement is towards the positive end of the microtubule unlike [[Dyneins|dyneins]], another type of [[Microtubules|microtubule]] motor protein which carry membrane-bound organelles towards the negative end of microtubules<ref>Alberts B., Johnson A., Lewis J., Raff M., Roberts K., Walter P. (2008) "Molecular Biology of the Cell, Page 1014 " 5th edition, New York, Garland Science</ref>.  


=== References  ===
=== References  ===


1. Alberts B., Johnson A., Lewis J., Raff M., Roberts K., Walter P. (2008) "Molecular Biology of the Cell, Page 1014 " 5th edition, New York, Garland Science
<references />
 
2. Berg JM, Tymoczko JL, Stryer L. Biochemistry. 5th edition. New York: W H Freeman; 2002. Section 34.3, Kinesin and Dynein Move Along Microtubules.

Latest revision as of 20:06, 5 December 2017

A microtubule motor protein first discovered in the giant axon of the quid, kinesins hydrolyse ATP to produce energy to move membrane-bound organelles along microtubules. Kinesins carry the membrane-bound organelles away from the neuronal cell body and towards the axon terminal. If mutations occur in kinesins can lead to disorders in the nervous system[1]. This movement is towards the positive end of the microtubule unlike dyneins, another type of microtubule motor protein which carry membrane-bound organelles towards the negative end of microtubules[2].

References

  1. ↑ Berg JM, Tymoczko JL, Stryer L. Biochemistry. 5th edition. New York: W H Freeman; 2002. Section 34.3, Kinesin and Dynein Move Along Microtubules.
  2. ↑ Alberts B., Johnson A., Lewis J., Raff M., Roberts K., Walter P. (2008) "Molecular Biology of the Cell, Page 1014 " 5th edition, New York, Garland Science
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