Oxidative decarboxylation: Difference between revisions
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Oxidative decarboxylation is a process in which carbon dioxide is produced through the removal of a carbon group as a result of [[Oxidation|oxidation reactions]].<ref>Voet, Donald; Voet, Judith; Pratt, Charlotte (2013). Fundamentals of Biochemistry (4 ed.). John Wiley and Sons.</ref><span style="line-height: 1.5em;"> There are vital in many biological processes such as the </span>[[Citric acid cycle|citric acid cycle]]<span style="line-height: 1.5em;">. </span> | Oxidative decarboxylation is a process in which carbon dioxide is produced through the removal of a carbon group as a result of [[Oxidation|oxidation reactions]].<ref>Voet, Donald; Voet, Judith; Pratt, Charlotte (2013). Fundamentals of Biochemistry (4 ed.). John Wiley and Sons.</ref><span style="line-height: 1.5em;"> There are vital in many biological processes such as the </span>[[Citric acid cycle|citric acid cycle]]<span style="line-height: 1.5em;">. </span> | ||
In the [[Citric acid cycle|citric acid cycle]] it is used three times to generate CO<sub>2</sub><sub> </sub>whilst also reducing [[NAD+|NAD]]<sup>[[NAD+|+]] </sup>to [[NADH|NADH]]. Firstly, pyruvate is converted by a [[Pyruvate Dehydrogenase Complex|pyruvate dehydrogenase]] complex to [[Acetyl CoA|Acetyl CoA]].<ref>Berg J.M, Tymoczko J.L, Stryer, L (2007). Biochemistry. 6th ed. New York: W. H. Freeman and Company. p477</ref><span style="line-height: 1.5em;"> Secondly, using the enzyme </span>[[Isocitrate dehydrogenase|Isocitrate dehydrogenase]]<span style="line-height: 1.5em;"> to </span>[[Α-Ketoglutarate|α-Ketoglutarate]]<span style="line-height: 1.5em;"> and finally </span>[[Α-Ketoglutarate dehydrogenase|α-Ketoglutarate dehydrogenase]]<span style="line-height: 1.5em;"> is used to convert</span>[[ | In the [[Citric acid cycle|citric acid cycle]] it is used three times to generate CO<sub>2</sub><sub> </sub>whilst also reducing [[NAD+|NAD]]<sup>[[NAD+|+]] </sup>to [[NADH|NADH]]. Firstly, pyruvate is converted by a [[Pyruvate Dehydrogenase Complex|pyruvate dehydrogenase]] complex to [[Acetyl CoA|Acetyl CoA]].<ref>Berg J.M, Tymoczko J.L, Stryer, L (2007). Biochemistry. 6th ed. New York: W. H. Freeman and Company. p477</ref><span style="line-height: 1.5em;"> Secondly, using the enzyme </span>[[Isocitrate dehydrogenase|Isocitrate dehydrogenase]]<span style="line-height: 1.5em;"> to </span>[[Α-Ketoglutarate|α-Ketoglutarate]]<span style="line-height: 1.5em;"> and finally </span>[[Α-Ketoglutarate dehydrogenase|α-Ketoglutarate dehydrogenase]]<span style="line-height: 1.5em;"> is used to convert</span>[[Αlpha-Ketoglutarate| α-Ketoglutarate]]<span style="line-height: 1.5em;"> to </span>[[Succinyl CoA|Succinyl CoA]]<span style="line-height: 1.5em;">.<ref>Berg J.M, Tymoczko J.L, Stryer, L (2007). Biochemistry. 6th ed. New York: W. H. Freeman and Company.</ref><ref>Berg J.M, Tymoczko J.L, Stryer, L (2007). Biochemistry. 6th ed. New York: W. H. Freeman and Company. p485</ref></span><br> | ||
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=== References === | === References === | ||
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Latest revision as of 15:46, 23 October 2015
Oxidative decarboxylation is a process in which carbon dioxide is produced through the removal of a carbon group as a result of oxidation reactions.[1] There are vital in many biological processes such as the citric acid cycle.
In the citric acid cycle it is used three times to generate CO2 whilst also reducing NAD+ to NADH. Firstly, pyruvate is converted by a pyruvate dehydrogenase complex to Acetyl CoA.[2] Secondly, using the enzyme Isocitrate dehydrogenase to α-Ketoglutarate and finally α-Ketoglutarate dehydrogenase is used to convert α-Ketoglutarate to Succinyl CoA.[3][4]
References
- ↑ Voet, Donald; Voet, Judith; Pratt, Charlotte (2013). Fundamentals of Biochemistry (4 ed.). John Wiley and Sons.
- ↑ Berg J.M, Tymoczko J.L, Stryer, L (2007). Biochemistry. 6th ed. New York: W. H. Freeman and Company. p477
- ↑ Berg J.M, Tymoczko J.L, Stryer, L (2007). Biochemistry. 6th ed. New York: W. H. Freeman and Company.
- ↑ Berg J.M, Tymoczko J.L, Stryer, L (2007). Biochemistry. 6th ed. New York: W. H. Freeman and Company. p485