Nuclear receptors: Difference between revisions
Jump to navigation
Jump to search
Created page with " Nuclear receptors are intracellular receptors, found in either in the cytosol or in the nucleus, bind ligands such as [[Steroid horm..." |
Added a link |
||
| (One intermediate revision by one other user not shown) | |||
| Line 1: | Line 1: | ||
Nuclear receptors are [[Intracellular receptors|intracellular receptors]], found in either in the [[Cytosol|cytosol]] or in the [[Nucleus|nucleus]], bind ligands such as [[Steroid hormones|steroid hormones]], thyroid hormones and fat-soluble [[Vitamin A|vitamin A]] and [[Vitamin D|vitamin D]]<ref>Chawla A., Repa J., Evans R., et al. Nuclear Receptors and Lipid Physiology. Opening the X-Files. Science 2001; 294(5548):1866-1870.</ref> . | |||
Binding of the ligand causes a conformational change in the receptor resulting in the dissociation of chaperone proteins from the receptor to reveal sequence specific binding sites. This increases its affinity of the nuclear-receptor complex for the specific chromosome binding site. Contrastingly, ligand binding can also act as a transcription repressor. Thus, nuclear receptors, along with their ligands work to regulate [[Transcription|transcription]] and [[Gene expression|gene expression]]<ref>Alberts B. Molecular biology of the cell. 5th ed. New York: Garland Science Taylor &amp; Francis. 2008</ref>. | Binding of the ligand causes a conformational change in the receptor resulting in the dissociation of chaperone proteins from the receptor to reveal sequence-specific binding sites. This increases its affinity of the nuclear-receptor complex for the specific chromosome binding site. Contrastingly, ligand binding can also act as a transcription repressor. Thus, nuclear receptors, along with their ligands work to regulate [[Transcription|transcription]] and [[Gene expression|gene expression]]<ref>Alberts B. Molecular biology of the cell. 5th ed. New York: Garland Science Taylor &amp;amp;amp; Francis. 2008</ref>. | ||
=== References === | === References === | ||
<references /> | <references /> | ||
Latest revision as of 16:29, 6 December 2018
Nuclear receptors are intracellular receptors, found in either in the cytosol or in the nucleus, bind ligands such as steroid hormones, thyroid hormones and fat-soluble vitamin A and vitamin D[1] .
Binding of the ligand causes a conformational change in the receptor resulting in the dissociation of chaperone proteins from the receptor to reveal sequence-specific binding sites. This increases its affinity of the nuclear-receptor complex for the specific chromosome binding site. Contrastingly, ligand binding can also act as a transcription repressor. Thus, nuclear receptors, along with their ligands work to regulate transcription and gene expression[2].