Acetyl-CoA: Difference between revisions
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Acetyl CoA (Acetyl coenzyme A) is a vital [[molecule|molecule]] which is needed in [[metabolism|metabolism]]. It's job is to transport 2 carbon atoms, using a high-energy linkage, in biosynthesis of a larger molecule(s)<ref>Bruce Alberts (2008). Molecular Biology of the Cell. New York: Garland Science. p83-84.</ref>. The rest of the [[molecule|molecule]] is used as a recognition site for specific [[enzymes|enzymes]]. <br>Acetyl CoA is used at the start the [[Krebs_cycle|Kreb's cycle]] ([[Krebs_cycle|Citric Cycle]]) where it is the product of the binding of [[CoA|CoA]] and [[pyruvate|pyruvate]]. This conversion of [[pyruvate|pyruvate]] into acetyl CoA consists of three steps: [[decarboxylation|decarboxylation]], [[Oxidation|oxidation]], and transfer of the resultant [[acetyl group|acetyl group]] to [[CoA|CoA]]<ref>Stryer, L., Berg, J. M. &amp;amp;amp; Tymoczko, J. L., 2002. Biochemistry. 5th ed. : W.H.Freeman &amp;amp;amp; Co Ltd.</ref>. The acetyl group then is transferred to [[oxaloacetate|oxaloacetate]] which forms [[citric acid|citric acid]], by the reaction of [[oxaloacetate|oxaloacetate]] with acetyl CoA and [[water|water]], which then goes through a a series of oxidations to produce energy rich activated carrier [[molecules|molecules]]. It can also be fed directly into the [[Krebs_cycle|Kreb's cycle]] via [[beta-oxidation|beta-oxidation]], where [[fatty acid|fatty acids]] are oxidised into qcetyl CoA, the process is carried out in [[Peroxisomes|peroxisomes]] and the resulting Acetyl CoA is expelled into [[Cytosol|cytosol]]. <br> | |||
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Revision as of 16:56, 10 January 2011
Acetyl CoA (Acetyl coenzyme A) is a vital molecule which is needed in metabolism. It's job is to transport 2 carbon atoms, using a high-energy linkage, in biosynthesis of a larger molecule(s)[1]. The rest of the molecule is used as a recognition site for specific enzymes.
Acetyl CoA is used at the start the Kreb's cycle (Citric Cycle) where it is the product of the binding of CoA and pyruvate. This conversion of pyruvate into acetyl CoA consists of three steps: decarboxylation, oxidation, and transfer of the resultant acetyl group to CoA[2]. The acetyl group then is transferred to oxaloacetate which forms citric acid, by the reaction of oxaloacetate with acetyl CoA and water, which then goes through a a series of oxidations to produce energy rich activated carrier molecules. It can also be fed directly into the Kreb's cycle via beta-oxidation, where fatty acids are oxidised into qcetyl CoA, the process is carried out in peroxisomes and the resulting Acetyl CoA is expelled into cytosol.